Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Risk of breast cancer in women with a CHEK2 mutation with and without a family history of breast cancer.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 1 Oct 2011

Cybulski Cezary, Wokołorczyk Dominika, Jakubowska Anna, Huzarski Tomasz, Byrski Tomasz, Gronwald Jacek, Masojć Bartłomiej, Deebniak Tadeusz, Górski Bohdan, Blecharz Paweł, Narod Steven A, Lubiński Jan

Abstract excerpt

PURPOSE: To estimate the risk of breast cancer in a woman who has a CHEK2 mutation depending on her family history of breast cancer. PATIENTS AND METHODS: Seven thousand four hundred ninety-four BRCA1 mutation-negative patients with breast cancer and 4,346 control women were genotyped for four founder mutations in CHEK2 (del5395, IVS2+1G>A, 1100delC, and I157T). RESULTS: A truncating mutation (IVS2+1G>A,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged, 80 and over
Share to Breast Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Checkpoint Kinase 2

Share to Family Health

Share to Follow-Up Studies

Share to Protein Serine-Threonine Kinases

Share to Risk Factors

Share to Young Adult

Source

Identifiers

PMID: 21876083
DOI: 10.1200/JCO.2010.34.0778

Genes

CHEK2
BRCA1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Risk of breast cancer in women with a CHEK2 mutation with and without a family history of breast cancer.PMID 21876083Read ↗

Low-penetrance susceptibility to breast cancer due to CHEK2(*)1100delC in noncarriers of BRCA1 or BRCA2 mutations.Semantic proximity Read ↗

Breast and colorectal cancer risks among over 6,000 CHEK2 pathogenic variant carriers: A comparison of missense versus truncating variants.Semantic proximity Read ↗

Management of individuals with germline pathogenic/likely pathogenic variants in CHEK2: A clinical practice resource of the American College of Medical Genetics and Genomics (ACMG).Semantic proximity Read ↗

Breast cancer risk is similar for CHEK2 founder and non-founder mutation carriers.Semantic proximity Read ↗

Increased risk of breast cancer associated with CHEK2*1100delC.Semantic proximity Read ↗

CHEK2*1100delC genotyping for clinical assessment of breast cancer risk: meta-analyses of 26,000 patient cases and 27,000 controls.Semantic proximity Read ↗

The CHEK2*1100delC allelic variant and risk of breast cancer: screening results from the Breast Cancer Family Registry.Semantic proximity Read ↗

Comparing Cancer Risk Management between Females with Truncating CHEK2 1100delC versus Missense CHEK2 I157T Variants.Semantic proximity Read ↗

Breast Cancer Survival and Tumor Characteristics in Premenopausal Women Carrying the <i>CHEK2*1100delC</i> Germline MutationSemantic proximity Read ↗

Breast cancer risk associated with CHEK2 mutations.Semantic proximity Read ↗

The CHEK2 gene and inherited breast cancer susceptibility.Semantic proximity Read ↗

Rare, evolutionarily unlikely missense substitutions in CHEK2 contribute to breast cancer susceptibility: results from a breast cancer family registry case-control mutation-screening study.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.