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Article

APC/Fizzy-Related targets Aurora-A kinase for proteolysis.

EMBO reports - 1 May 2002

Castro Anna, Arlot-Bonnemains Yannick, Vigneron Suzanne, Labbé Jean-Claude, Prigent Claude, Lorca Thierry

Abstract excerpt

Aurora-A kinase is a mitotic spindle-pole-associated protein that has been implicated in duplication and separation of centrosomes and in spindle assembly. The proper timing and amplitude of Aurora-A expression seems to be important, as elevated levels of this protein have been associated with centrosome abnormalities and aneuploidy in mammalian cells. We show that Aurora-A increases at the G2-M transistion and...

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Identifiers

PMID: 11964384
DOI: 10.1093/embo-reports/kvf095
PMCID: PMC1084108

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APC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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APC/Fizzy-Related targets Aurora-A kinase for proteolysis.PMID 11964384Read ↗

Investigating how ubiquitin-mediated proteolysis of AURKA contributes to its activity in the cell cycleSemantic proximity Read ↗

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Aurora-A: the maker and breaker of spindle poles.Semantic proximity Read ↗

Aurora-A kinase is essential for bipolar spindle formation and early development.Semantic proximity Read ↗

Aurora kinases link chromosome segregation and cell division to cancer susceptibility.Semantic proximity Read ↗

Identification of a new APC/C recognition domain, the A box, which is required for the Cdh1-dependent destruction of the kinase Aurora-A during mitotic exit.Semantic proximity Read ↗

The Drosophila cell cycle gene fizzy is required for normal degradation of cyclins A and B during mitosis and has homology to the CDC20 gene of Saccharomyces cerevisiae.Semantic proximity Read ↗

Aurora A Regulates Prometaphase Progression by Inhibiting the Ability of RASSF1A to Suppress APC-Cdc20 ActivitySemantic proximity Read ↗

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Aurora A Is Essential for Early Embryonic Development and Tumor SuppressionSemantic proximity Read ↗

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Aurora-A Kinase Maintains the Fidelity of Early and Late Mitotic Events in HeLa CellsSemantic proximity Read ↗

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