Article

Role of <i>Chymotrypsin-like Elastase 1</i> in Lung Physiology and in α1-Antitrypsin Deficiency

2017-05-16

Abstract excerpt

α1-antitrypsin related lung disease (AAT-RLD) is the fourth leading indication for lung transplantation and is characterized by protease-mediated progressive emphysema that manifests in the 4 th or 5 th decade of life. Chymotrypsin-like elastase 1 ( Cela1 ) is a digestive enzyme that binds to elastin in a stretch-dependent manner and is covalently neutralized by AAT. We hypothesized a role for Cela1 in AAT-RL...

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Literature Corpus work: 724a771c-21b2-520f-914b-88f3a09661f0
DOI: 10.1101/138776

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