Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The murine Spi-2 proteinase inhibitor locus: a multigene family with a hypervariable reactive site domain.

The EMBO journal - 1 Feb 1991

Inglis J D, Hill R E

Abstract excerpt

We have isolated 10 closely linked members of a proteinase inhibitor multigene family from the inbred mouse strain 129. These sequences, termed the Serine Proteinase Inhibitor 2 (Spi-2) genes, appear to have been derived from a common ancestor represented in man by the single copy alpha 1-antichymotrypsin gene. The genes are clustered on two cloned genomic DNA segments spanning 220 kb, and have at least partially...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Base Sequence
Share to Binding Sites

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cloning, Molecular

Share to Genetic Variation

Share to Molecular Sequence Data

Share to Restriction Mapping

Source

Open in PubMed Open full text

Identifiers

PMID: 1991447
DOI: 10.1002/j.1460-2075.1991.tb07945.x
PMCID: PMC452641

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The murine Spi-2 proteinase inhibitor locus: a multigene family with a hypervariable reactive site domain.PMID 1991447Read ↗

Functional diversification during evolution of the murine alpha(1)-proteinase inhibitor family: role of the hypervariable reactive center loop.Semantic proximity Read ↗

Expression patterns of murine antichymotrypsin-like genes reflect evolutionary divergence at the Serpina3 locus.Semantic proximity Read ↗

Evolution of kallikrein-related peptidases in mammals and identification of a genetic locus encoding potential regulatory inhibitorsSemantic proximity Read ↗

Evolution of murine alpha 1-proteinase inhibitors: gene amplification and reactive center divergence.Semantic proximity Read ↗

Accelerated evolution in the reactive centre regions of serine protease inhibitors.Semantic proximity Read ↗

Rediscovering ACE: novel insights into the many roles of the angiotensin-converting enzyme.Semantic proximity Read ↗

Human and mouse proteases: a comparative genomic approachSemantic proximity Read ↗

Patterns of divergence during evolution of alpha 1-proteinase inhibitors in mammals.Semantic proximity Read ↗

A survey of H2 gene sequences, including new wild-derived genes.Semantic proximity Read ↗

Tissue-specific Expression Patterns and Fine Mapping of the Human Kallikrein (KLK) Locus on Proximal 19q13.4Semantic proximity Read ↗

Evolution of the rat kallikrein gene family: gene conversion leads to functional diversity.Semantic proximity Read ↗

Comparative analysis of the mouse and human peptidylarginine deiminase gene clusters reveals highly conserved non-coding segments and a new human gene, PADI6Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.