The murine Spi-2 proteinase inhibitor locus: a multigene family with a hypervariable reactive site domain.

doi:10.1002/j.1460-2075.1991.tb07945.x

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Article

The murine Spi-2 proteinase inhibitor locus: a multigene family with a hypervariable reactive site domain.

The EMBO journal - 1 Feb 1991

Inglis J D, Hill R E

Abstract excerpt

We have isolated 10 closely linked members of a proteinase inhibitor multigene family from the inbred mouse strain 129. These sequences, termed the Serine Proteinase Inhibitor 2 (Spi-2) genes, appear to have been derived from a common ancestor represented in man by the single copy alpha 1-antichymotrypsin gene. The genes are clustered on two cloned genomic DNA segments spanning 220 kb, and have at least partially...

Topics

Amino Acid Sequence
Animals
Base Sequence
Binding Sites
Cloning, Molecular
Cosmids
Exons
Gene Library
Genetic Variation
Humans
Introns
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Multigene Family

Oligonucleotide Probes

Restriction Mapping

Sequence Homology, Nucleic Acid

Serine Proteinase Inhibitors

Source

Open in PubMed Open full text

Identifiers

PMID: 1991447
DOI: 10.1002/j.1460-2075.1991.tb07945.x
PMCID: PMC452641

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1991447-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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