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Article

Mutations on the hinge region of leukocyte elastase inhibitor determine the loss of inhibitory function.

Biochemical and biophysical research communications - 11 Aug 2000

Perani P, Zeggai S, Torriglia A, Courtois Y

Abstract excerpt

Leukocyte elastase inhibitor (LEI) is a cytosolic component of lung macrophages and blood leukocytes that inhibits neutrophil elastase. LEI is a member of the serpin superfamily, these proteins, mostly protease inhibitors, are thought to undergo a conformational change upon complex formation with proteinase that involves partial insertion of the hinge region of the reactive centre loop into a beta-sheet of the...

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Identifiers

PMID: 10924364
DOI: 10.1006/bbrc.2000.3191

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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