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Article

Production of tetraketide lactones by mutated Antirrhinum majus chalcone synthases (AmCHS1).

Journal of bioscience and bioengineering - 1 Aug 2010

Hatayama Masayoshi, Unno Hideaki, Kusunoki Masami, Takahashi Seiji, Nishino Tokuzo, Nakayama Toru

Abstract excerpt

Chalcone synthase (CHS) is a key enzyme of flavonoid biosynthesis in higher plants, catalyzing the stepwise decarboxylative condensation of three acetate units from malonyl-CoA with p-coumaroyl-CoA to yield 2',4,4',6'-tetrahydroxychalcone (THC). Reaction (at pH 7.5) of a mutant (V196M/T197A) of Antirrhinum majus CHS (AmCHS1) with p-coumaroyl-CoA and malonyl-CoA yielded a significant amount of a non-chalcone...

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PMID: 20547380
DOI: 10.1016/j.jbiosc.2010.02.010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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