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Chemoenzymatic Synthesis and Biological Evaluation for Bioactive Molecules Derived from Bacterial Benzoyl Coenzyme A Ligase and Plant Type III Polyketide Synthase.

Biomolecules - 9 May 2020

Adhikari Kamal, Lo I-Wen, Chen Chun-Liang, Wang Yung-Lin, Lin Kuan-Hung, Zadeh Saeid Malek, Rattinam Rajesh, Li Yi-Shan, Wu Chang-Jer, Li Tsung-Lin

Abstract excerpt

Plant type III polyketide synthases produce diverse bioactive molecules with a great medicinal significance to human diseases. Here, we demonstrated versatility of a stilbene synthase (STS) from Pinus Sylvestris, which can accept various non-physiological substrates to form unnatural polyketide products. Three enzymes (4-coumarate CoA ligase, malonyl-CoA synthetase and engineered benzoate CoA ligase) along with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 32397467
DOI: 10.3390/biom10050738
PMCID: PMC7277991

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