Article
Effect of the mutation (C3435T) at exon 26 of the MDR1 gene on expression level of MDR1 messenger ribonucleic acid in duodenal enterocytes of healthy Japanese subjects.
Clinical pharmacology and therapeutics - 1 Apr 2002
Nakamura Tsutomu, Sakaeda Toshiyuki, Horinouchi Masanori, Tamura Takao, Aoyama Nobuo, Shirakawa Toshiro, Matsuo Masafumi, Kasuga Masato, Okumura Katsuhiko
Abstract excerpt
The effect of the C3435T mutation at exon 26 of the MDR1 gene on the expression levels of MDR1 messenger ribonucleic acid (mRNA) was evaluated by means of real-time polymerase chain reaction in 51 biopsy specimens of duodenum obtained from 13 healthy Japanese subjects. The mRNA levels of MDR1 were 0.38 +/- 0.15, 0.56 +/- 0.14, and 1.13 +/- 0.42 (mean value +/- SE) in the subjects with the homozygote of wild-type...
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