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Article

The effects of the human MDR1 genotype on the expression of duodenal P-glycoprotein and disposition of the probe drug talinolol.

Clinical pharmacology and therapeutics - 1 Nov 2002

Siegmund Werner, Ludwig Karen, Giessmann Thomas, Dazert Peter, Schroeder Eike, Sperker Bernhard, Warzok Rolf, Kroemer Heyo K, Cascorbi Ingolf

Abstract excerpt

BACKGROUND AND OBJECTIVES: A single-nucleotide polymorphism (SNP) of the human multidrug-resistance gene in wobble position of exon 26 reportedly predicts expression and function of P-glycoprotein in human enterocytes and lymphocytes. Several other allelic variants of MDR1 have been identified, some of which lead to amino acid exchange with as yet unknown functional relevance. METHODS: In healthy white...

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Identifiers

PMID: 12426521
DOI: 10.1067/mcp.2002.127739

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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