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Human intestinal P‐glycoprotein activity estimated by the model substrate digoxin

13 Nov 2006

Abstract excerpt

OBJECTIVE: P-glycoprotein (Pgp) plays a part in the intestinal uptake of xenobiotics and has been associated with susceptibility to ulcerative colitis. The aim of this study was to examine Pgp activity in relation to age, gender, medical treatment (rifampicin or ketoconazole) and the multidrug resistance (MDR1) gene single nucleotide polymorphisms (SNPs) G2677T and C3435T using the model drug digoxin. MATERIAL...

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PMID: 17365992
DOI: 10.1080/00365510600986084

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