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Article

Mast Cells: A Cellular Link Between Autoantibodies and Inflammatory Arthritis

5 Sept 2002

Abstract excerpt

Previous studies have revealed that autoantibodies, complement components, and Fc receptors each participate in the pathogenesis of erosive arthritis in K/BxN mice. However, it is not known which cellular populations are responsive to these inflammatory signals. We find that two strains of mice deficient in mast cells, W/Wv and Sl/Sld, were resistant to development of joint inflammation and that susceptibility...

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PMID: 12215644
DOI: 10.1126/science.1073176

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