Article
Induction of tolerance in arthritogenic B cells with receptors of differing affinity for self-antigen.
Proceedings of the National Academy of Sciences of the United States of America - 7 Mar 2006
Huang Haochu, Kearney John F, Grusby Michael J, Benoist Christophe, Mathis Diane
Abstract excerpt
Multiple mechanisms of tolerance induction limit autoimmunity, but their relative contribution for lymphocytes recognizing self-antigens of differing availability is incompletely understood. The mechanisms applied to arthritogenic B cells expressing antigen-specific B cell receptors (BCRs) with different affinities for glucose-6-phosphate isomerase (GPI) were examined in the corresponding Ig gene knock-in mice....
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