Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Glucose-6-phosphate isomerase variants play a key role in the generation of anti-GPI antibodies: possible mechanism of autoantibody production.

Biochemical and biophysical research communications - 15 Oct 2004

Muraki Yoshifumi, Matsumoto Isao, Chino Yusuke, Hayashi Taichi, Suzuki Eiji, Goto Daisuke, Ito Satoshi, Murata Hideyuki, Tsutsumi Akito, Sumida Takayuki

Abstract excerpt

Glucose-6-phosphate isomerase (GPI), recognized as an autoantigen in the K/BxN arthritis model, is a ubiquitous cytoplasmic enzyme. Anti-GPI antibodies (Abs) are also detected in the serum of patients with arthritic diseases including rheumatoid arthritis (RA). So far, 24 GPI variants have been reported and most of these variants relate to non-spherocytic hemolytic disease. To understand the mechanisms of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Arthritis, Rheumatoid
Share to Autoantibodies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Deletion

Share to Glucose-6-Phosphate Isomerase

Share to Isoenzymes

Share to Leukocytes, Mononuclear

Share to Sequence Analysis, Protein

Share to Sequence Homology, Amino Acid

Source

Identifiers

PMID: 15369782
DOI: 10.1016/j.bbrc.2004.08.123

Genes

GPI

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Glucose-6-phosphate isomerase variants play a key role in the generation of anti-GPI antibodies: possible mechanism of autoantibody production.PMID 15369782Read ↗

A functional variant of Fcgamma receptor IIIA is associated with rheumatoid arthritis in individuals who are positive for anti-glucose-6-phosphate isomerase antibodies.Semantic proximity Read ↗

Human platelet antigens in disease.Semantic proximity Read ↗

Molecular genetics, biochemistry, and biology of PNH.Semantic proximity Read ↗

Arthritogenic Monoclonal Antibodies from K/BxN MiceSemantic proximity Read ↗

Glucosephosphate isomerase (GPI) deficiency mutations associated with hereditary nonspherocytic hemolytic anemia (HNSHA).Semantic proximity Read ↗

A Novel Mutation of Glucose Phosphate Isomerase (GPI) Causing Severe Neonatal Anemia Due to GPI DeficiencySemantic proximity Read ↗

Anti-glucose-6-phosphate isomerase, anti-cyclic citrullinated peptide antibodies and HLA-DRB1 genotypes in Japanese patients with early rheumatoid arthritis.Semantic proximity Read ↗

Combined glucose-6-phosphate dehydrogenase and glucosephosphate isomerase deficiency can alter clinical outcome.Semantic proximity Read ↗

Glycosyl phosphatidylinositol-linked glycoconjugates: structure, biosynthesis and function.Semantic proximity Read ↗

The significance of autoantibodies against β2-glycoprotein ISemantic proximity Read ↗

Understanding the structure of β2-glycoprotein I: new insights and future paths for antiphospholipid syndromeSemantic proximity Read ↗

Hereditary non-spherocytic hemolytic anemia and severe glucose phosphate isomerase deficiency in an Indian patient homozygous for the L487F mutation in the human GPI gene.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.