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Article

Transmission of antibody-induced arthritis is independent of complement component 4 (C4) and the complement receptors 1 and 2 (CD21/35).

European journal of immunology - 1 Mar 2002

Solomon Samuel, Kolb Cornelia, Mohanty Subhasis, Jeisy-Walder Elvira, Preyer Rosemarie, Schöllhorn Volkmar, Illges Harald

Abstract excerpt

The K/BxN murine model of rheumatoid arthritis (RA) is dependent on the specificity of the KRN alpha beta-TCR, to recognize glucose-6-phosphate-isomerase (GPI) on the NOD MHC class II A(g7) allele and production of GPI-specific autoantibodies. Transfer of K/BxN serum into MHC-unrelated and lymphocyte-deficient mice induces RA. To investigate whether K/BxN serum-induced RA involves complement activation and/or the...

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Share to Arthritis, Experimental
Share to Complement C4

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Glucose-6-Phosphate Isomerase

Share to Receptors, Antigen, T-Cell, alpha-beta

Share to Receptors, Complement 3b

Share to Receptors, Complement 3d

Share to Receptors, IgG

Source

Identifiers

PMID: 11857338
DOI: 10.1002/1521-4141(200203)32:3<644::AID-IMMU644>3.0.CO;2-5

Genes

GPI

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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