Article
A functional variant of Fcgamma receptor IIIA is associated with rheumatoid arthritis in individuals who are positive for anti-glucose-6-phosphate isomerase antibodies.
Arthritis research & therapy - 1 Jan 2005
Matsumoto Isao, Zhang Hua, Muraki Yoshifumi, Hayashi Taichi, Yasukochi Takanori, Kori Yuko, Goto Daisuke, Ito Satoshi, Tsutsumi Akito, Sumida Takayuki
Abstract excerpt
Anti-glucose-6-phosphate isomerase (GPI) antibodies are known to be arthritogenic autoantibodies in K/BxN mice, although some groups have reported that few healthy humans retain these antibodies. The expression of Fcgamma receptors (FcgammaRs) is genetically regulated and has strong implications for the development of experimental arthritis. The interaction between immune complexes and FcgammaRs might therefore...
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