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Article

Autoreactive marginal zone B cells are spontaneously activated but lymph node B cells require T cell help.

The Journal of experimental medicine - 7 Aug 2006

Mandik-Nayak Laura, Racz Jennifer, Sleckman Barry P, Allen Paul M

Abstract excerpt

In K/BxN mice, arthritis is induced by autoantibodies against glucose-6-phosphate-isomerase (GPI). To investigate B cell tolerance to GPI in nonautoimmune mice, we increased the GPI-reactive B cell frequency using a low affinity anti-GPI H chain transgene. Surprisingly, anti-GPI B cells were not tolerant to this ubiquitously expressed and circulating autoantigen. Instead, they were found in two functionally...

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Source

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Identifiers

PMID: 16880262
DOI: 10.1084/jem.20060701
PMCID: PMC2118363

Genes

GPI

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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