Article
Germline mutation of the RET proto-oncogene in members of Slovak families with multiple endocrine neoplasia 2.
Neoplasma - 1 Jan 2001
Poturnajova M, Altanerov V, Kettmann R, Feikova S, Hlubinova K, Balazovjech I, Breza J, Fodo G, Knotek J, Matoska J, Podobov M, Altaner C
Abstract excerpt
Detection of mutations in RET proto-oncogene in Slovak families from different localities and of different ethnic origin with MEN 2 syndrome is reported. Despite the fact that the same mutation of RET oncogene was found in different family members, the latency period of tumor appearance and their pathogenicity differed substantially. In addition, also different phenotypes of the disease were expressed in various...
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