Article
Multiple endocrine neoplasias type 2B and RET proto-oncogene.
Italian journal of pediatrics - 19 Mar 2012
Martucciello Giuseppe, Lerone Margherita, Bricco Lara, Tonini Gian Paolo, Lombardi Laura, Del Rossi Carmine G, Bernasconi Sergio
Abstract excerpt
Multiple Endocrine Neoplasia type 2B (MEN 2B) is an autosomal dominant complex oncologic neurocristopathy including medullary thyroid carcinoma, pheochromocytoma, gastrointestinal disorders, marphanoid face, and mucosal multiple ganglioneuromas. Medullary thyroid carcinoma is the major cause of mortality in MEN 2B syndrome, and it often appears during the first years of life. RET proto-oncogene germline...
Topics
- Biopsy
- Child
- Child, Preschool
- Codon
- Gene Expression
- Genetic Predisposition to Disease
- Humans
- Infant
- Lymph Node Excision
- Multiple Endocrine Neoplasia Type 2b
- Point Mutation
- Prognosis
- Proto-Oncogene Mas
- Proto-Oncogene Proteins c-ret