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Article

RET proto-oncogene in the development of human cancer.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 1 Jan 1999

Eng C

Abstract excerpt

The RET proto-oncogene, located on chromosome subband 10q11.2, encodes a receptor tyrosine kinase expressed in tissues and tumors derived from neural crest. Germline (present in every cell of the body) mutations in RET cause multiple endocrine neoplasia type 2 (MEN 2), an inherited cancer syndrome characterized by medullary thyroid carcinoma (MTC), pheochromocytoma (PC), and hyperparathyroidism (HPT). This...

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Source

Identifiers

PMID: 10458257
DOI: 10.1200/JCO.1999.17.1.380

Genes

RET

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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