Clinical significance of RET mutation screening in a pedigree of multiple endocrine neoplasia type 2A.

doi:10.3892/mmr.2016.5371

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Article

Clinical significance of RET mutation screening in a pedigree of multiple endocrine neoplasia type 2A.

Molecular medicine reports - 1 Aug 2016

Ying Rongbiao, Feng Jun

Abstract excerpt

The clinical characteristics and RET proto-oncogene (RET‑PO) mutation status of a patient with multiple endocrine neoplasia type 2A pedigree (MEN2A) was analyzed with the aim of preliminarily exploring the molecular mechanisms and clinical significance of the disease. Clinical characteristics of a single MEN2A patient were analyzed. Genomic DNA was extracted from the peripheral blood of the proband and 10 family...

Topics

Adult
Biomarkers
DNA Mutational Analysis
Female
Follow-Up Studies
Genetic Testing
Humans
Male
Middle Aged
Multiple Endocrine Neoplasia Type 2a
Mutation
Pedigree
Phenotype
Proto-Oncogene Mas
Proto-Oncogene Proteins c-ret
Treatment Outcome
Young Adult

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Open in PubMed

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PMID: 27277749
DOI: 10.3892/mmr.2016.5371

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