Article
Somatic mutations of the RET proto-oncogene are not required for tumor development in multiple endocrine neoplasia type 2 (MEN 2) gene carriers.
Cancer research - 1 Nov 1996
Landsvater R M, de Wit M J, Zewald R A, Hofstra R M, Buys C H, Ploos van Amstel H K, Höppener J W, Lips C J
Abstract excerpt
Germ line mutations in one allele of the RET proto-oncogene predispose to the multiple endocrine neoplasia type 2 (MEN 2) syndromes. To investigate whether these inherited mutations alone can cause the development of tumors in vivo (oncogene model) or whether somatic mutations in the homologous RET allele are required for tumorigenesis (tumor suppressor gene model), we analyzed the entire coding region of both...
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