Article
P73 expression in basal layers of head and neck squamous epithelium: a role in differentiation and carcinogenesis in concert with p53 and p63?
Oncogene - 30 Aug 2001
Faridoni-Laurens L, Bosq J, Janot F, Vayssade M, Le Bihan M L, Kaghad M, Caput D, Bénard J, Ahomadegbe J C
Abstract excerpt
P73, a p53-homologue gene, has been studied for its possible role in head and neck squamous epithelium (HNSE) differentiation and carcinogenesis. P73 RNA and protein were analysed in 50 biopsies, including well- and moderately-differentiated carcinomas, and 21 matched normal adjacent tissues. P73 immunohistochemical analyses revealed intense p73 nuclear staining in basal and parabasal cells of normal squamous...
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