Article
Role of the newer p53 family proteins in malignancy.
Apoptosis : an international journal on programmed cell death - 1 Jan 2000
Irwin M S, Kaelin W G
Abstract excerpt
The most recently identified members of the p53 family, p63 and p73, share certain structural and functional similarities with p53. Both p63 and p73 can bind to canonical p53-DNA-binding sites, transactivate the promoters of known p53 target genes and induce apoptosis. Despite these similarities there are many important differences. In contrast to p53, p63 and p73 give rise to multiple distinct protein isoforms...
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