Article
Expression of the p53 homologues p63 and p73 in multiple simultaneous gastric cancer.
The Journal of pathology - 1 Sept 2001
Tannapfel A, Schmelzer S, Benicke M, Klimpfinger M, Kohlhaw K, Mössner J, Engeland K, Wittekind C
Abstract excerpt
The tumour-suppressor protein p53 has recently been shown to belong to a family that includes two structurally related proteins, p63 and p73. This study investigated the status of p53 and its two homologues in multiple simultaneous gastric carcinomas. Expression and mutation of p53, p73 and p63 including the two major isotypes TAp63 and black triangleNp63, were examined by direct DNA-sequencing, in situ...
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