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Article

SecY and SecA interact to allow SecA insertion and protein translocation across the Escherichia coli plasma membrane.

The EMBO journal - 3 Nov 1997

Matsumoto G, Yoshihisa T, Ito K

Abstract excerpt

SecA, the preprotein-driving ATPase in Escherichia coli, was shown previously to insert deeply into the plasma membrane in the presence of ATP and a preprotein; this movement of SecA was proposed to be mechanistically coupled with preprotein translocation. We now address the role played by SecY, the central subunit of the membrane-embedded heterotrimeric complex, in the SecA insertion reaction. We identified a...

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Identifiers

PMID: 9351821
DOI: 10.1093/emboj/16.21.6384
PMCID: PMC1170245

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

SecY and SecA interact to allow SecA insertion and protein translocation across the Escherichia coli plasma membrane.PMID 9351821Read ↗

Roles of SecG in ATP- and SecA-dependent protein translocation.Semantic proximity Read ↗

Dimeric SecA is essential for protein translocation.Semantic proximity Read ↗

A SecE mutation that modulates SecY-SecE translocase assembly, identified as a specific suppressor of SecY defects.Semantic proximity Read ↗

Characterization of a mutant form of SecA that alleviates a SecY defect at low temperature and shows a synthetic defect with SecY alteration at high temperature.Semantic proximity Read ↗

Genetic dissection of SecA: suppressor mutations against the secY205 translocase defect.Semantic proximity Read ↗

Arginine 357 of SecY is needed for SecA-dependent initiation of preprotein translocation.Semantic proximity Read ↗

Protein translocation functions of Escherichia coli SecY: in vitro characterization of cold-sensitive secY mutants.Semantic proximity Read ↗

Translocation of proteins through the Sec61 and SecYEG channels.Semantic proximity Read ↗

The SecY translocation complex: convergence of genetics and structure.Semantic proximity Read ↗

Multiple SecA molecules drive protein translocation across a single translocon with SecG inversion.Semantic proximity Read ↗

Superactive SecY variants that fulfill the essential translocation function with a reduced cellular quantity.Semantic proximity Read ↗

Syd, a SecY-interacting protein, excludes SecA from the SecYE complex with an altered SecY24 subunit.Semantic proximity Read ↗

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