Article
SecA interacts with ribosomes in order to facilitate posttranslational translocation in bacteria.
Molecular cell - 4 Feb 2011
Huber Damon, Rajagopalan Nandhakishore, Preissler Steffen, Rocco Mark A, Merz Frieder, Kramer Günter, Bukau Bernd
Abstract excerpt
In Escherichia coli, translocation of exported proteins across the cytoplasmic membrane is dependent on the motor protein SecA and typically begins only after synthesis of the substrate has already been completed (i.e., posttranslationally). Thus, it has generally been assumed that the translocation machinery also recognizes its protein substrates posttranslationally. Here we report a specific interaction between...
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