Article
The role of mismatch repair gene defects in the development of adenomas in patients with HNPCC.
Gastroenterology - 1 Jan 2004
De Jong Andrea E, Morreau Hans, Van Puijenbroek Marjo, Eilers Paul H c, Wijnen Juul, Nagengast Fokko M, Griffioen Gerrit, Cats Annemieke, Menko Fred H, Kleibeuker Jan H, Vasen Hans F A
Abstract excerpt
BACKGROUND AND AIMS: The adenoma-carcinoma sequence in hereditary nonpolyposis colorectal cancer (HNPCC) is accelerated. It remains unknown whether the mismatch repair (MMR) defect also promotes the development of adenomas. The aim of this study was to compare the risk of developing colorectal ad...
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