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Article

A novel mechanism of cell killing by anti-topoisomerase II bisdioxopiperazines.

The Journal of biological chemistry - 21 Jan 2000

Jensen L H, Nitiss K C, Rose A, Dong J, Zhou J, Hu T, Osheroff N, Jensen P B, Sehested M, Nitiss J L

Abstract excerpt

Bisdioxopiperazines are a unique class of topoisomerase II inhibitors that lock topoisomerase II at a point in the enzyme reaction cycle where the enzyme forms a closed clamp around DNA. We examined cell killing by ICRF-187 and ICRF-193 in yeast cells expressing human topoisomerase II alpha (htop-IIalpha). Expression of htop-IIalpha in yeast cells sensitizes them to both ICRF-187 and ICRF-193, compared with cells...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 10636919
DOI: 10.1074/jbc.275.3.2137

Genes

RAD52

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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