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Article

TP53 mutation analysis of malignant peripheral nerve sheath tumors.

Journal of neuropathology and experimental neurology - 1 Jan 2010

Verdijk Robert M, den Bakker Michael A, Dubbink Hendrikus J, Hop Wim C J, Dinjens Winand N M, Kros Johan M

Abstract excerpt

Mutations in TP53 underlie the development of malignant peripheral nerve sheath tumors (MPNSTs) in animal models, but there is controversy regarding the extent of TP53 mutations in human MPNSTs. We assessed the TP53 mutation frequency in 145 consecutive cases from our department over 36 years; 88 cases were histologically confirmed as MPNSTs, and corresponding clinical data were reviewed. Mutation analysis of...

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PMID: 20010306
DOI: 10.1097/NEN.0b013e3181c55d55

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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