Article
Prostanoids, ornithine decarboxylase, and polyamines in primary chemoprevention of familial adenomatous polyposis.
Gastroenterology - 1 Feb 2004
Giardiello Francis M, Casero Robert A, Hamilton Stanley R, Hylind Linda M, Trimbath Jill D, Geiman Deborah E, Judge Katharine R, Hubbard Walter, Offerhaus G Johan A, Yang Vincent W
Abstract excerpt
BACKGROUND & AIMS: Familial adenomatous polyposis because of germline mutation of the adenomatous polyposis coli gene is characterized by development of colorectal adenomas and, ultimately, colorectal cancer. The usefulness of colorectal mucosal compounds to predict the effect on adenoma development of primary chemoprevention with the nonsteroidal anti-inflammatory drug sulindac was evaluated. METHODS: A...
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