Article
Molecular analysis of sulindac-resistant adenomas in familial adenomatous polyposis.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Dec 2001
Keller J J, Offerhaus G J, Drillenburg P, Caspers E, Musler A, Ristimäki A, Giardiello F M
Abstract excerpt
PURPOSE: Sulindac causes the reduction of adenomas in familial adenomatous polyposis (FAP) patients, but complete regression is unusual, and breakthrough of colorectal carcinoma during sulindac treatment has been described. The molecular features related to sulindac resistance are unknown. Therefore, we investigated molecular alterations in adenomas from FAP patients with complete adenoma regression on sulindac...
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