Pheromone response in yeast: association of Bem1p with proteins of the MAP kinase cascade and actin.

doi:10.1126/science.270.5239.1210

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Article

Pheromone response in yeast: association of Bem1p with proteins of the MAP kinase cascade and actin.

Science (New York, N.Y.) - 17 Nov 1995

Leeuw T, Fourest-Lieuvin A, Wu C, Chenevert J, Clark K, Whiteway M, Thomas D Y, Leberer E

Abstract excerpt

Haploid cells of the yeast Saccharomyces cerevisiae respond to mating pheromones with polarized growth toward the mating partner. This morphological response requires the function of the cell polarity establishment protein Bem1p. Immunochemical and two-hybrid protein interaction assays revealed that Bem1p interacts with two components of the pheromone-responsive mitogen-activated protein (MAP) kinase cascade,...

Topics

Actins
Adaptor Proteins, Signal Transducing
Calcium-Calmodulin-Dependent Protein Kinases
Carrier Proteins
Cell Polarity
Fungal Proteins
GTP-Binding Proteins
Intracellular Signaling Peptides and Proteins
MAP Kinase Kinase Kinases
Mating Factor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Morphogenesis

Mutation

Peptides

Pheromones

Protein Serine-Threonine Kinases

Saccharomyces cerevisiae

Saccharomyces cerevisiae Proteins

Source

Open in PubMed

Identifiers

PMID: 7502048
DOI: 10.1126/science.270.5239.1210

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7502048-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Pheromone response in yeast: association of Bem1p with proteins of the MAP kinase cascade and actin.PMID 7502048Read ↗

Genetic interactions indicate a role for Mdg1p and the SH3 domain protein Bem1p in linking the G-protein mediated yeast pheromone signalling pathway to regulators of cell polarity.Semantic proximity Read ↗

New Features Surrounding the Cdc42-Ste20 Module that Regulates MAP Kinase Signaling in YeastSemantic proximity Read ↗

Counteractive control of polarized morphogenesis during mating by mitogen-activated protein kinase Fus3 and G1 cyclin-dependent kinase.Semantic proximity Read ↗

Identification of genes required for normal pheromone-induced cell polarization in Saccharomyces cerevisiae.Semantic proximity Read ↗

A positive feedback loop stabilizes the guanine-nucleotide exchange factor Cdc24 at sites of polarization.Semantic proximity Read ↗

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The rho-GAP encoded by BEM2 regulates cytoskeletal structure in budding yeast.Semantic proximity Read ↗

Identification of novel, evolutionarily conserved Cdc42p-interacting proteins and of redundant pathways linking Cdc24p and Cdc42p to actin polarization in yeast.Semantic proximity Read ↗

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Association of the yeast pheromone response G protein beta gamma subunits with the MAP kinase scaffold Ste5p.Semantic proximity Read ↗

Synthetic lethal analysis implicates Ste20p, a p21-activated potein kinase, in polarisome activation.Semantic proximity Read ↗

The role of Far1p in linking the heterotrimeric G protein to polarity establishment proteins during yeast mating.Semantic proximity Read ↗

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