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Article

Pheromone response in yeast: association of Bem1p with proteins of the MAP kinase cascade and actin.

Science (New York, N.Y.) - 17 Nov 1995

Leeuw T, Fourest-Lieuvin A, Wu C, Chenevert J, Clark K, Whiteway M, Thomas D Y, Leberer E

Abstract excerpt

Haploid cells of the yeast Saccharomyces cerevisiae respond to mating pheromones with polarized growth toward the mating partner. This morphological response requires the function of the cell polarity establishment protein Bem1p. Immunochemical and two-hybrid protein interaction assays revealed that Bem1p interacts with two components of the pheromone-responsive mitogen-activated protein (MAP) kinase cascade,...

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PMID: 7502048
DOI: 10.1126/science.270.5239.1210

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Pheromone response in yeast: association of Bem1p with proteins of the MAP kinase cascade and actin.PMID 7502048Read ↗

Genetic interactions indicate a role for Mdg1p and the SH3 domain protein Bem1p in linking the G-protein mediated yeast pheromone signalling pathway to regulators of cell polarity.Semantic proximity Read ↗

New Features Surrounding the Cdc42-Ste20 Module that Regulates MAP Kinase Signaling in YeastSemantic proximity Read ↗

Counteractive control of polarized morphogenesis during mating by mitogen-activated protein kinase Fus3 and G1 cyclin-dependent kinase.Semantic proximity Read ↗

Identification of genes required for normal pheromone-induced cell polarization in Saccharomyces cerevisiae.Semantic proximity Read ↗

A positive feedback loop stabilizes the guanine-nucleotide exchange factor Cdc24 at sites of polarization.Semantic proximity Read ↗

A yeast gene (BEM1) necessary for cell polarization whose product contains two SH3 domains.Semantic proximity Read ↗

The rho-GAP encoded by BEM2 regulates cytoskeletal structure in budding yeast.Semantic proximity Read ↗

Identification of novel, evolutionarily conserved Cdc42p-interacting proteins and of redundant pathways linking Cdc24p and Cdc42p to actin polarization in yeast.Semantic proximity Read ↗

Role of Cdc42p in pheromone-stimulated signal transduction in Saccharomyces cerevisiae.Semantic proximity Read ↗

Association of the yeast pheromone response G protein beta gamma subunits with the MAP kinase scaffold Ste5p.Semantic proximity Read ↗

Synthetic lethal analysis implicates Ste20p, a p21-activated potein kinase, in polarisome activation.Semantic proximity Read ↗

The role of Far1p in linking the heterotrimeric G protein to polarity establishment proteins during yeast mating.Semantic proximity Read ↗

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