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Article

Regulation of cell polarity by interactions of Msb3 and Msb4 with Cdc42 and polarisome components.

Molecular and cellular biology - 1 Oct 2005

Tcheperegine Serguei E, Gao Xiang-Dong, Bi Erfei

Abstract excerpt

In Saccharomyces cerevisiae, polarized growth depends on interactions between the actin cytoskeleton and the secretory machinery. Here we show that the Rab GTPase-activating proteins (GAPs) Msb3 and Msb4 interact directly with Spa2, a scaffold protein of the "polarisome" that also interacts with the formin Bni1. Spa2 is required for the polarized localization of Msb3 and Msb4 at the bud tip. We also show that...

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Identifiers

PMID: 16166638
DOI: 10.1128/MCB.25.19.8567-8580.2005
PMCID: PMC1265733

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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