Cdk1 coordinates cell-surface growth with the cell cycle.

doi:10.1038/ncb1568

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Article

Cdk1 coordinates cell-surface growth with the cell cycle.

Nature cell biology - 1 May 2007

McCusker Derek, Denison Carilee, Anderson Scott, Egelhofer Thea A, Yates John R, Gygi Steven P, Kellogg Douglas R

Abstract excerpt

The mechanisms that control cell growth during the cell cycle are poorly understood. In budding yeast, cyclin dependent kinase 1 (Cdk1) triggers polarization of the actin cytoskeleton and bud emergence in late G1 through activation of the Cdc42 GTPase. However, Cdk1 is not thought to be required for subsequent growth of the bud. Here, we show that Cdk1 has an unexpected role in controlling bud growth after bud...

Topics

Actins
Adaptor Proteins, Signal Transducing
CDC2 Protein Kinase
Cell Cycle
Cell Polarity
Cyclin G
Cyclins
Enzyme Inhibitors
Exocytosis
Fungal Proteins
GTP-Binding Protein alpha Subunits, Gi-Go

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Green Fluorescent Proteins

Guanine Nucleotide Exchange Factors

Kluyveromyces

Multiprotein Complexes

Mutation

Phosphorylation

Pyrazoles

Source

Open in PubMed

Identifiers

PMID: 17417630
DOI: 10.1038/ncb1568

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