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Article

The role of Far1p in linking the heterotrimeric G protein to polarity establishment proteins during yeast mating.

Science (New York, N.Y.) - 20 Nov 1998

Butty A C, Pryciak P M, Huang L S, Herskowitz I, Peter M

Abstract excerpt

Heterotrimeric guanosine triphosphate (GTP)-binding proteins (G proteins) determine tissue and cell polarity in a variety of organisms. In yeast, cells orient polarized growth toward the mating partner along a pheromone gradient by a mechanism that requires Far1p and Cdc24p. Far1p bound Gbetagamma and interacted with polarity establishment proteins, which organize the actin cytoskeleton. Cells containing mutated...

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PMID: 9822386
DOI: 10.1126/science.282.5393.1511

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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The role of Far1p in linking the heterotrimeric G protein to polarity establishment proteins during yeast mating.PMID 9822386Read ↗

Site-specific regulation of the GEF Cdc24p by the scaffold protein Far1p during yeast mating.Semantic proximity Read ↗

FAR1 is required for oriented polarization of yeast cells in response to mating pheromones.Semantic proximity Read ↗

Gbetagamma recruits Rho1 to the site of polarized growth during mating in budding yeast.Semantic proximity Read ↗

A GTP-exchange factor required for cell orientation.Semantic proximity Read ↗

Phosphorylation of Gβ is crucial for efficient chemotropism in yeast.Semantic proximity Read ↗

Nuclear export of Far1p in response to pheromones requires the export receptor Msn5p/Ste21p.Semantic proximity Read ↗

Nucleocytoplasmic shuttling of the Cdc42p exchange factor Cdc24p.Semantic proximity Read ↗

The Rsr1/Bud1 GTPase interacts with itself and the Cdc42 GTPase during bud-site selection and polarity establishment in budding yeast.Semantic proximity Read ↗

Genetic interactions indicate a role for Mdg1p and the SH3 domain protein Bem1p in linking the G-protein mediated yeast pheromone signalling pathway to regulators of cell polarity.Semantic proximity Read ↗

A positive feedback loop stabilizes the guanine-nucleotide exchange factor Cdc24 at sites of polarization.Semantic proximity Read ↗

Counteractive control of polarized morphogenesis during mating by mitogen-activated protein kinase Fus3 and G1 cyclin-dependent kinase.Semantic proximity Read ↗

Distinct roles for two Galpha-Gbeta interfaces in cell polarity control by a yeast heterotrimeric G protein.Semantic proximity Read ↗

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