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Article

A GTP-exchange factor required for cell orientation.

Nature - 8 Jan 1998

Nern A, Arkowitz R A

Abstract excerpt

The Rho-family of GTPases and their regulators are essential for cytoskeletal reorganization and transcriptional activation in response to extracellular signals. Little is known about what links these molecules to membrane receptors. In the budding yeast Saccharomyces cerevisiae, haploid cells respond to mating pheromone through a G-protein-coupled receptor and the betagamma subunit of the G protein, resulting in...

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PMID: 9428768
DOI: 10.1038/34458

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

A GTP-exchange factor required for cell orientation.PMID 9428768Read ↗

Role for the Rho-family GTPase Cdc42 in yeast mating-pheromone signal pathway.Semantic proximity Read ↗

Gbetagamma recruits Rho1 to the site of polarized growth during mating in budding yeast.Semantic proximity Read ↗

The exchange factor Cdc24 is required for cell fusion during yeast mating.Semantic proximity Read ↗

The role of Far1p in linking the heterotrimeric G protein to polarity establishment proteins during yeast mating.Semantic proximity Read ↗

Polarization of the yeast pheromone receptor requires its internalization but not actin-dependent secretion.Semantic proximity Read ↗

Cdc42p GDP/GTP cycling is necessary for efficient cell fusion during yeast mating.Semantic proximity Read ↗

Phosphorylation of Gβ is crucial for efficient chemotropism in yeast.Semantic proximity Read ↗

The Rsr1/Bud1 GTPase interacts with itself and the Cdc42 GTPase during bud-site selection and polarity establishment in budding yeast.Semantic proximity Read ↗

Site-specific regulation of the GEF Cdc24p by the scaffold protein Far1p during yeast mating.Semantic proximity Read ↗

A positive feedback loop stabilizes the guanine-nucleotide exchange factor Cdc24 at sites of polarization.Semantic proximity Read ↗

Distinct roles for two Galpha-Gbeta interfaces in cell polarity control by a yeast heterotrimeric G protein.Semantic proximity Read ↗

AKR1 encodes a candidate effector of the G beta gamma complex in the Saccharomyces cerevisiae pheromone response pathway and contributes to control of both cell shape and signal transduction.Semantic proximity Read ↗

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