Article
Von Hippel-Lindau disease and sporadic renal cell carcinoma.
Cancer surveys - 1 Jan 1995
Zbar B
Abstract excerpt
The VHL gene, isolated by positional cloning, encodes a protein of 284 aminoacids that has no homology with other proteins in the databases. The nucleotide sequence lacks domains that would suggest (a) a DNA binding protein, (b) nuclear localization, (c) enzymatic activity or (d) membrane localiz...
Topics
- Adrenal Gland Neoplasms
- Carcinoma, Renal Cell
- Chromosomes, Human, Pair 3
- Chromosomes, Human, Pair 8
- Genes, Tumor Suppressor
- Genotype
- Humans
- Kidney Neoplasms
- Ligases
- Methylation
- Mutation
- Phenotype
- Pheochromocytoma
- Proteins
- Sequence Deletion
- Translocation, Genetic
- Tumor Suppressor Proteins
- Ubiquitin-Protein Ligases