Article
Apolipoprotein E variation at the sequence haplotype level: implications for the origin and maintenance of a major human polymorphism.
American journal of human genetics - 1 Oct 2000
Fullerton S M, Clark A G, Weiss K M, Nickerson D A, Taylor S L, Stengârd J H, Salomaa V, Vartiainen E, Perola M, Boerwinkle E, Sing C F
Abstract excerpt
Three common protein isoforms of apolipoprotein E (apoE), encoded by the epsilon2, epsilon3, and epsilon4 alleles of the APOE gene, differ in their association with cardiovascular and Alzheimer's disease risk. To gain a better understanding of the genetic variation underlying this important polymorphism, we identified sequence haplotype variation in 5.5 kb of genomic DNA encompassing the whole of the APOE locus...
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