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Article

Mechanisms of G1 checkpoint loss in resected early stage non-small cell lung cancer.

Lung cancer (Amsterdam, Netherlands) - 1 Apr 2001

Zhou J X, Niehans G A, Shar A, Rubins J B, Frizelle S P, Kratzke R A

Abstract excerpt

Loss of the G1 checkpoint appears to be extremely common among virtually all neoplasms. A variety of genetic and epigenetic mechanisms have been demonstrated to play significant roles in this process. In a consecutive series of early stage non-small cell lung cancer (NSCLC), we have established the loss of expression of the G1 Cdk inhibitors p15INK4b) and p16INK4a by DNA methylation is very common (37%), and...

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PMID: 11282426
DOI: 10.1016/s0169-5002(00)00210-5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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