Article
Mesenteric lymph nodes are critical for the induction of high-dose oral tolerance in the absence of Peyer's patches.
European journal of immunology - 1 Apr 2002
Spahn Thomas W, Weiner Howard L, Rennert Paul D, Lügering Norbert, Fontana Adriano, Domschke Wolfram, Kucharzik Torsten
Abstract excerpt
We have previously demonstrated the loss of oral tolerance (OT) in lymphotoxinalpha-/- (LTalpha-/-) and TNFalpha / lymphotoxinalpha deficient (TNFalpha / LTalpha-/-) mice which have defective Peyer's patches (PP) and lymph node (LN) development. We have now studied OT in BALB / c mice with differential defects of the gut-associated lymphoid tissue (GALT) caused by inhibition of LTbetaR signaling during fetal...
Topics
- Administration, Oral
- Animals
- Antibodies, Monoclonal
- Antigens
- Antigens, CD
- Dose-Response Relationship, Immunologic
- Female
- Genotype
- Hypersensitivity, Delayed
- Immune Tolerance