Article
Distinct roles for lymphotoxin-alpha and tumor necrosis factor in organogenesis and spatial organization of lymphoid tissue.
European journal of immunology - 1 Oct 1997
Körner H, Cook M, Riminton D S, Lemckert F A, Hoek R M, Ledermann B, Köntgen F, Fazekas de St Groth B, Sedgwick J D
Abstract excerpt
Specialized roles for the pro-inflammatory cytokines tumor necrosis factor (TNF) and lymphotoxin (LT) were characterized in TNF/LT alpha -/- and TNF -/- mice established by direct gene targeting of C57BL/6 ES cells. The requirement for LT early in lymphoid tissue organogenesis is shown to be dist...
Topics
- Animals
- Antibody Formation
- B-Lymphocytes
- Cell Adhesion Molecules
- Immunoglobulins
- Immunologic Deficiency Syndromes
- Lymph Nodes
- Lymphoid Tissue
- Lymphotoxin-alpha
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- Morphogenesis
- Mucoproteins
- Peyer's Patches