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Article

Lymphotoxin-alpha-deficient mice make delayed, but effective, T and B cell responses to influenza.

Journal of immunology (Baltimore, Md. : 1950) - 1 Nov 2002

Lund Frances E, Partida-Sánchez Santiago, Lee Byung O, Kusser Kimberly L, Hartson Louise, Hogan Robert J, Woodland David L, Randall Troy D

Abstract excerpt

Lymphotoxin-alpha(-/-) (LTalpha(-/-)) mice are thought to be unable to generate effective T and B cell responses. This is attributed to the lack of lymph nodes and the disrupted splenic architecture of these mice. However, despite these defects we found that LTalpha(-/-) mice could survive infection with a virulent influenza A virus. LTalpha(-/-) mice and normal wild-type mice infected with influenza A generated...

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Source

Identifiers

PMID: 12391242
DOI: 10.4049/jimmunol.169.9.5236

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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