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Article

Requirement for the p75 TNF-alpha receptor 2 in the regulation of airway hyperresponsiveness by gamma delta T cells.

Journal of immunology (Baltimore, Md. : 1950) - 15 Oct 2002

Kanehiro Arihiko, Lahn Michael, Mäkelä Mika J, Dakhama Azzeddine, Joetham Anthony, Rha Yeong-Ho, Born Willi, Gelfand Erwin W

Abstract excerpt

In a recent study, we found that TNF-alpha negatively regulates airway responsiveness through the activation of gammadelta T cells. The biological activities of TNF-alpha are mediated by two structurally related but functionally distinct receptors, p55 (TNFR1) and p75 (TNFR2), which are independently expressed on the cell surface. However, the relative importance of either TNFR in airway hyperresponsiveness (AHR)...

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Source

Identifiers

PMID: 12370348
DOI: 10.4049/jimmunol.169.8.4190

Genes

AHR
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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