Article
Absence of lymph nodes in lymphotoxin-alpha(LT alpha)-deficient mice is due to abnormal organ development, not defective lymphocyte migration.
Journal of inflammation - 1 Jan 1995
Mariathasan S, Matsumoto M, Baranyay F, Nahm M H, Kanagawa O, Chaplin D D
Abstract excerpt
Mice homozygous for a targeted null mutation of lymphotoxin-alpha (LT alpha) are born without lymph nodes (LN) or Peyer's patches (PP) and with altered splenic architecture. To investigate the mechanism of failed LN organogenesis, we transferred bone marrow (BM) from Thy 1.2 LT alpha-deficient or Thy 1.2 wild type mice to lethally irradiated 8-12-week-old Thy 1.1 wild type recipients. Six to 10 weeks later,...
Topics
- Animals
- Bone Marrow Transplantation
- Embryonic and Fetal Development
- Flow Cytometry
- L-Selectin
- Lymph Nodes
- Lymphocytes
- Lymphotoxin-alpha
- Mice
- Mice, Mutant Strains
- Mutation