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Article

Secreted Lymphotoxin-α Is Essential for the Control of an Intracellular Bacterial Infection

15 Jan 2001

Abstract excerpt

Although the essential role of tumor necrosis factor (TNF) in the control of intracellular bacterial infection is well established, it is uncertain whether the related cytokines lymphotoxin-alpha (LTalpha3) and lymphotoxin-beta (LTbeta) have independent roles in this process. Using C57Bl/6 mice in which the genes for these cytokines have been disrupted, we have examined the relative contribution of secreted...

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PMID: 11208864
DOI: 10.1084/jem.193.2.239

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