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Article

The APC/β‐catenin pathway in ulcerative colitis–related colorectal carcinomas

1 Mar 2002

Abstract excerpt

BACKGROUND: Although the APC/beta-catenin pathway is known to play a crucial role in sporadic colorectal carcinogenesis, its influence on ulcerative colitis (UC)-related neoplastic progression is unknown. To elucidate the role of the APC-/beta-catenin pathway in UC-related carcinogenesis, the authors identified APC and beta-catenin mutations in a set of UC-related and sporadic colorectal carcinomas. METHODS: The...

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PMID: 11920497
DOI: 10.1002/cncr.10334

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