Article
Colitic Cancer Develops Through Mutational Alteration Distinct from that in Sporadic Colorectal Cancer: A Comparative Analysis of Mutational Rates at Each Step.
Cancer genomics & proteomics - 1 Jan 2000
Tanaka Toshiaki, Kobunai Takashi, Yamamoto Yoko, Emoto Shigenobu, Murono Koji, Kaneko Manabu, Sasaki Kazuhito, Otani Kensuke, Nishikawa Takeshi, Kawai Kazushige, Hata Keisuke, Nozawa Hiroaki, Watanabe Toshiaki
Abstract excerpt
BACKGROUND: Patients with ulcerative colitis (UC) are at risk of UC-associated colorectal cancer (CRC); however, little is known about genetic alterations occurring during UC carcinogenesis. We examined mutational changes in patients with colitic cancer and the features that differed between the carcinogenesis of UC and sporadic CRC. MATERIAL AND METHODS: Specimens were obtained from the non-neoplastic mucosa and...
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