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Article

Mutational analysis differentiating sporadic carcinomas from colitis-associated colorectal carcinomas.

Cell communication and signaling : CCS - 10 Oct 2024

Dregelies Theresa, Haumaier Franziska, Sterlacci William, Backert Steffen, Vieth Michael

Abstract excerpt

BACKGROUND: Ulcerative colitis (UC) is a chronic inflammatory bowel disease (IBD) that is associated with increased risk of developing colitis-associated carcinoma (CAC). The genetic profile of CACs is fairly similar to the sporadic colorectal carcinomas (sCRCs), although showing certain differences in the timing and sequence of alterations that contribute to carcinogenesis. Also, both cancer types typically show...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39390564
DOI: 10.1186/s12964-024-01856-8
PMCID: PMC11465924

Genes

APC
ATM
KRAS
PIK3CA

Variants

Provenance

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