Article
The UNC-73/Trio RhoGEF-2 domain is required in separate isoforms for the regulation of pharynx pumping and normal neurotransmission in C. elegans.
Genes & development - 1 Sept 2005
Steven Robert, Zhang Lijia, Culotti Joseph, Pawson Tony
Abstract excerpt
In both Caenorhabditis elegans and Drosophila, UNC-73/Trio functions in axon guidance by signaling through the Rac GTPase to regulate cytoskeletal rearrangements necessary for growth cone migrations. Here, we show that the complex C. elegans unc-73 gene encodes at least eight differentially expressed UNC-73 intracellular protein isoforms. Previously reported mutations affecting UNC-73 isoforms encoding the...
Topics
- Animals
- Animals, Genetically Modified
- Caenorhabditis elegans
- Caenorhabditis elegans Proteins
- Female
- Gene Expression
- Guanine Nucleotide Exchange Factors
- Male
- Mutation
- Nerve Tissue Proteins