Article
Dosage-sensitive, reciprocal genetic interactions between the Abl tyrosine kinase and the putative GEF trio reveal trio's role in axon pathfinding.
Neuron - 1 Apr 2000
Liebl E C, Forsthoefel D J, Franco L S, Sample S H, Hess J E, Cowger J A, Chandler M P, Shupert A M, Seeger M A
Abstract excerpt
The Abelson tyrosine kinase (Abl) is integrated into signal transduction networks regulating axon outgrowth. We have identified the Drosophila trio gene through a mutation that exacerbates the Abl mutant phenotype. Drosophila Trio is an ortholog of mammalian Trio, a protein that contains multiple spectrin-like repeats and two Dbl homology (DH) domains that affect actin cytoskeletal dynamics via the small GTPases...
Topics
- Animals
- Axons
- Central Nervous System
- Drosophila
- Drosophila Proteins
- Gene Dosage
- Genes, abl
- Genotype
- Guanine Nucleotide Exchange Factors
- Molecular Sequence Data